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relatively low amplitude, during attempts at maximal voluntary contraction The latter may mimic a nascent pattern seen in severe denervation and early reinnervation Careful observation may demonstrate a slight increase in the overall amplitude of the electrical activity with prolonged muscle activation, but this is a dif cult impression to quantitate As with repetitive stimulation, the same panoramic selection of muscles should be tested including proximal and distal muscles in both upper and lower extremities as well as those innervated by cranial nerves As the bulbar muscles (eg, masseter, orbicularis oculi and nasalis, hypoglossus, and trapezius muscles) are usually affected rst, these tend to demonstrate greater degrees of abnormality than their limb counterparts Pathological MUAP changes in these muscles may be dif cult to detect, however, as MUAPs in facial muscles are small under normal circumstances as a result of their low innervation ratio With symptom progression and increasing time from disease onset (greater than 10 days), there may be a signi cant reduction in both the numbers and the duration/amplitude of MUAPs and an increased prevalence of positive sharp waves and brillation potentials This is especially true for profound disease in the proximal limb and cranial muscles After several months, there tends to be a rather complete electrophysiologic recovery with respect to MUAP parameters The morphological changes of MUAPs in botulism are explained by mechanisms similar to many myopathies or other DNMT As NMT fails in muscle bers that are in close proximity to the needle electrode, their contribution to the amplitude of the MUAP diminishes As NMT fails in myo bers belonging to that same motor unit but at the periphery of the recording radius of the needle electrode, their contributions to the duration of the MUAP are lost As the synchrony between all of the single muscle ber action potentials contributing to that MUAP is altered by NMT failure in random bers, MUAP polyphasia may occur As NMT failure in a myo ber may effectively denervate it, abnormal spontaneous activity in the form of brillation potentials and positive waves may occur The small number of patients studied with SFEMG allow only a cursory description of what is typical for botulism363,369,378,387,393 395 Predictably, abnormal (increased) jitter values and blocking can be observed early in the disease in 40 50% of SFEMG studies It would appear that, unlike MG, the degree of blocking is somewhat independent of the severity of jitter The mechanism for this is uncertain, although it has been hypothesized that it may be related in part to the acuity of disease onset and the associated impaired quantal content A nding in botulism that is similar to LEMS is the tendency for jitter values to decline in association with an increased frequency of muscle ber action potentials This in all probability due to the same physiological fac-.

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An SIS file can have multiple signatures, allowing for applications that require manufacturer approval to be signed by multiple roots The signature field is nested within the SISController field The signature covers every field within the SISController field except for the SISDataIndex field at the end This includes previous signatures This can be seen in Figure 7-8 The SISDataIndex field is not included because it is modified whenever an SIS file is embedded within another one At first glance, this does not appear to preclude modification of the SISData field After all, the signature only covers the SISController field However, within the SISController field is the SISInstallBlock field consisting of an array of SISFileDescription fields These SISFileDescription entries include an SHA-1 hash of the contents of the corresponding files within the SISData block Attempts to manipulate the files directly will invalidate this hash, and manipulating this hash invalidates the digital signature Signatures can be created from arbitrary certificate/private key pairs, including self-signed However, the capabilities available to an SIS installation package will be limited to the extent that the signatures validate to a set of trusted roots Different trust roots can certify different capabilities In this fashion, it may be necessary to have multiple signatures to have access to all of the capabilities requested

a) Press the power button and allow the system to boot Did the system boot properly ____________________________________________________ b) Log on in a normal fashion so that you are viewing the operating system desktop Were you able to log on as normal ________________________________________________ c) Use the mouse to select Start | My Computer and double-click the icon that represents the optical-media drive This should enable you to view the contents of the disc that was inserted prior to the forced power down List some of the contents of the disc: ______________________________________________ ____________________________________________________________________________ d) Use the mouse to select Start | Shut Down In the Shut Down Windows box, select Shut down from the drop-down list This performs a graceful shutdown of the system

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