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75 Kende, M; Alving, C R; Rill, W L; Swartz, G M; Canonico, P G Enhanced ef cacy of liposome-encapsulated ribavirin against Rift Valley fever virus infection in mice Antimicrob Agents Chemother 1985, 27, 903 907 76 Kende, M; Lupton, H W; Rill, W L; Levy, H B; Canonico, P G Enhanced therapeutic ef cacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice Antimicrob Agents Chemother 1987, 31, 986 990 77 Garcia, S; Crance, J M; Billecocq, A; Peinnequin, A; Jouan, A; Bouloy, M; Garin, D Quantitative real-time PCR detection of Rift Valley fever virus and its application to evaluation of antiviral compounds J Clin Microbiol 2001, 39, 4456 4461 78 Crance, J M; Gratier, D; Guimet, J; Jouan, A.

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Table 21.9 Skeletal Abnormalities Commonly Seen in Teratogenicity Tests Digits Polydactyly presence of extra digits, in mouse six or more, instead of ve Syndactyly fusion of two or more digits Oligodactyly absence of one or more digits Brachydactyly smallness of one or more digits Ribs Wavy ribs may be any aberrant shape Extra may have extra ribs on either side Fused may be fused anywhere along the length of the rib Branched single base and branched Tail Short short tail, usually lack of vertebrae Missing absence of tail Corkscrew corkscrew-shaped tail

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Inhibition of sand y fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds Res Virol 1997, 148, 353 365 79 Sidwell, R W; Huffman, J H; Barnard, D L; Smee, D F; Warren, R P; Chirigos, M A; Kende, M; Huggins, J Antiviral and immunomodulating inhibitors of experimentally induced Punta Toro virus infections Antiviral Res 1994, 25, 105 122 80 Smee, D F; Alaghamandan, H A; Kini, G D; Robins, R K Antiviral activity and mode of action of ribavirin 50 -sulfamate against Semliki Forest virus Antiviral Res 1988, 10, 253 262 81 De Clercq, E; Cools, M; Balzarini, J; Snoeck, R; Andrei, G; Hosoya, M; Shigeta, S; Ueda, T; Minakawa, N; Matsuda, A Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide and related-compounds Antimicrob Agents Chemother 1991, 35, 679 684 82.

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dosage group are treated during the nal third of gestation and through lactation to weaning (day 15 of pregnancy through day 21 postpartum) (Figure 21.4). The duration of gestation, parturition problems, and the number and size of pups in the naturally delivered litter are observed, as is the growth performance or the offspring. Variations of this test are the inclusion of groups treated only to parturition and only postpartum in order to separate prenatal and postnatal effects. Cross-fostering of pups to untreated dams may also be used to the same end. Behavioral testing of the pups has been suggested, and this and other physiological testing is to be recommended.

Hence, Eq. (17.13) holds. However, P tj0 satis es a Markov renewal equation, as in Cinlar [9, Section 10.3]; that is, for j T k, Pjk tj0 and Pjj tj0 Gjc t so that P tj0 D t Q t P tj0 where denotes convolution, and Eq. (17.14) holds. j P

This general heading is used to include brief assessments of tests that are not always required but that may be required in certain cases or that have been suggested as useful adjuncts to current testing protocols. Many are in areas of toxicology that are developing rapidly; as a result no consensus has yet evolved as to the best tests or sequence of tests, only an understanding that such evaluations may shed light on previously unde ned aspects of chemical toxicity.

De Clercq, E; Murase, J; Marquez, V E Broad-spectrum antiviral and cytocidal activity of cyclopentenylcytosine, a carbocyclic nucleoside targeted at CTP synthetase Biochem Pharmacol 1991, 41, 1821 1829 83 van Tiel, F H; Harmsen, M; Kraaijeveld, C A; Snippe, H Inhibition of Semliki Forest virus multiplication by ribavirin a potential method for the monitoring of antiviral agents in serum J Virol Methods 1986, 14, 119 125 84 Briolant, S; Garin, D; Scaramozzino, N; Jouan, A; Crance, J M In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination Antiviral Res 2004, 61, 111 117 85 Crance, J M; Scaramozzino, N; Jouan, A; Garin, D Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic aviviruses Antiviral Res 2003, 58, 73 79 86 Neyts, J; Meerbach, A.

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